He was one of the Seventy appointed by Christ Himself. After Christ's Ascension, Quadratus preached the Gospel in Athens, then served as a bishop in Athens, then in Magnesia. He was stoned by the pagans, then imprisoned and starved to death in prison. It is said that he wrote a defense of the Christian faith which caused the Emperor Hadrian to decree that Christians were not to be persecuted without special cause. He was buried in Magnesia.