A devout Christian from his early youth, he was kidnapped from his native Chios and impressed into the army. When he openly confessed himself a Christian, his commander ordered him to make sacrifice to the gods. When he resolutely refused, the commander ordered him to be beaten with iron flails, then had his tongue cut out. But even without a tongue, Isidore was miraculously enabled to speak, and clearly proclaimed the name of Christ. At the same moment, the commander was struck mute. The commander then ordered by signs that Isidore be beheaded. Isidore went to his death rejoicing and praising God. This occurred during the persecutions of the Emperor Decius.